How to order
Prometrium (progesterone) 400mg soft vaginal capsules are available in packs of 15.
Prometrium is available via Alliance Healthcare.
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Prometrium® (progesterone) 400mg soft vaginal capsules dosing and administration
Discover information on dosing and administration for the UK’s first and only licensed progesterone treatment for the prevention of miscarriage in women with a history of recurrent miscarriage who present with bleeding in the first trimester.¹
Prometrium dosing¹
The recommended dose of Prometrium is 400mg twice a day (morning and night).
Treatment should be initiated during the first trimester of pregnancy, at the first sign of vaginal bleeding, and should continue to the 16th week of gestation.
Prometrium contraindications¹
Hypersensitivity to the active substance or to any of the excipients listed in the SmPC.
- Jaundice
- Severe hepatic dysfunction
- Undiagnosed vaginal bleeding
- Mammary or genital tract carcinoma
- Thrombophlebitis
- Thromboembolic disorders
- Cerebral haemorrhage
- Porphyria
- Allergy to nuts or soya
Prometrium administration¹
Each Prometrium 400mg soft vaginal capsule must be inserted deep into the vagina.
Learn more how you can support your patients on using Prometrium.
Patient support items
Explore guidance and resources to support your patients on their Prometrium journey.
References
- Prometrium 400mg soft vaginal capsules Summary of Product Characteristics. Available at:
https://www.medicines.org.uk/emc/product/16016/smpcAccessed June 2026
June 2026 | MAT-PROMO-PTM-0097
Adverse event reporting
Adverse events should be reported. Reporting forms and information can be found at https://yellowcard.mhra.gov.uk/or search for MHRA Yellow Card in the Google Play or Apple App Store. Adverse events should also be reported to Besins Healthcare (UK) Ltd Drug Safety on 0203 862 0920 or Email: drugsafety@besins-healthcare.com
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